Typhoid is spread by infected human waste, so safe food, clean water, improved sanitation, and good hygiene (WASH) practices are key to preventing the disease. Because of the significant burden of typhoid and the growing threat of drug resistance, the role of vaccines alongside WASH interventions is critical in high-risk, typhoid-endemic areas. This is especially important among rural and hard-to-reach communities where progress in medical services, infrastructure, and development may be slow. Additionally, typhoid vaccines are valuable for travelers, food workers (including street vendors), household contacts of typhoid carriers, and laboratory workers.

CompositionTyphoid (polysaccharide) conjugate vaccine

Suspension for injection in multidose vial, for IM injection into the anterolateral part of the thigh in children < 2 years and into the deltoid muscle in children.

Dosage and vaccination schedule

Child and adult: 0.5 ml single dose

Routine vaccination

Child at 9 months or during the 2nd year of life: one single dose at the same time as other recommended vaccines. Follow national recommendations.

Catch-up vaccination: Child up to 15 years: one single dose.

Vaccination schedule

  • Single dose at 9-12 through 23 months followed by a booster at 2 years of age
  • Single dose at 9-12 through 23 months followed by a booster at 2 years of age
  • Single dose at 2 years
  • Revaccination every 3 years

Side effects

  • Injection site reactions (pain, tenderness, redness, swelling, or a hard lump),
  • Low fever,
  • Nausea,
  • Diarrhea,
  • Stomach pain, or
  • Headache.


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Media Contact:
John Kimberly
Editorial Manager
Journal of Vaccines & Vaccination
Email: jvv@scholarlypub.com